A eficiência do GH rDNA é muito significativa independente de sua aplicação primária (somatotrofina) que tem indicação específica para crescimento estatural (altura) longitudinal. Essas aplicações se tornaram possíveis depois da descoberta em 1985 pela Genentech da enzima com uma espécie de função estilete, que eliminava o reconhecimento individual de quem pertencia o DNA, descartando diversas doenças graves como a formação de príons ou DCJ – doença de Creutzfeldt Jakob. O balanço nitrogenado negativo em pacientes criticamente enfermos é parcialmente atribuível à resistência ao GH assim como uma redução da produção e ação do IGF-1 (fator de crescimento insulina símile-1).
A este respeito, a avaliação da secreção de GH por intermédio de testes que podem explorar os caminhos fisiológicos envolvidos na produção do hormônio de crescimento parece importante, em caso de deficiência imprescindível. Além disso, alguma evidência clínica sugere que os estímulos farmacológicos causam a liberação hipofisária de GH armazenado talvez indisponíveis em condições fisiológicas, e para tanto existem necessidades que envolvem a complementação ou liberação do GH nessas situações.
HORMONE GH GROWTH AND STATES CATABOLIC WHETHER IN CHILDREN'S CHILDREN YOUTH AND ADULTS EVEN AND ITS BENEFITS HIGHLIGHTS.
GH - GROWTH HORMONE, ACTIONS ANABOLIC HEALTHY WELL RECOGNIZED THE GH STIMULATE EMPLOYMENT IN SUCH HORMONE STAT CATABOLIC (OPPOSITE), INCLUDING SURGERY, BURNS, PARENTERAL NUTRITION, BANKRUPTCY ORGANIC, AND BENEFITS FOR THOSE WHO HAVE DISABILITIES IMMUNOLOGICAL, THE BENEFITS ARE THESE CONDITIONS OBVIOUS, BUT MUST BE USED WITH MASTERY FOR PROFESSIONAL ENDOCRINOLOGISTS: PHYSIOLOGY-ENDOCRINOLOGY-NEUROENDOCRINOLOGY-GENETICS-ENDOCRINE-PEDIATRICS (SUBDIVISION OF ENDOCRINOLOGY): DR. JOÃO SANTOS CAIO JR. ET DRA. HENRIQUETA VERLANGIERI CAIO.
GH Efficiency - growth hormone by DNA - recombinant is significant regardless of their primary application (somatotropin), which has specific indication for height growth (height) longitudinal. These applications became possible after the discovery in 1985 by Genentech, the enzyme with a sort of stylus function, which eliminated the individual recognition of who belonged DNA, discarding several serious diseases such as the formation of prions or CJD - Creutzfeldt Jakob disease. The negative nitrogen balance in critically ill patients is partly attributable to the strength of the growth hormone GH-as well as a reduction in production and IGF -1 action (insulin-like growth factor). GH - growth hormone administered in post-surgical patients, as well as in normal individuals who are receiving hypocaloric intravenous feeding, results in the reversal to positive nitrogen balance. Beneficial effects have been reported with extensive burns, in patients receiving treatment with glucocorticoids in high doses, in patients with chronic obstructive pulmonary disease, in cancer patients with congestive heart failure (Williams -2012), however the published studies are in progress. When the GH - growth hormone by DNA - recombinant was administered in elderly and malnourished patients, this substance has shown excellent efficacy and exciting adjunct to dietary increase.
It is obvious that any use in elderly people must be given in cases of adequate indication of proper doses and according to the need of the patient's disability, and with proper scientific knowledge. Many advances characterize research into the diagnosis of short stature in children. Increasing evidence shows a continuous spectrum of growth hormone (GH) output in patients deficient in GH and low normal children. Although identical biological human GH could theoretically provide the opportunity to treat children with slow growth, it is not certain that all the normal short children with a poor growth rate could benefit from therapy due to drug cost and cost of treatment while the patient and parents have few alternatives. In fact, in addition to axiological findings, assessment of GH secretion remains essential in selecting candidates for therapy. In this regard, the evaluation of GH secretion by means of tests that can explore the physiological pathways involved in production of the hormone seems important in case of essential deficiency. Furthermore some clinical evidence suggests that pharmacological stimuli cause release of pituitary GH perhaps unavailable stored under physiological conditions, and so there needs involving complementation or release of GH - Growth hormone in these situations.
GH Y ESTABLECE DESTACADOS YA SEA EN NIÑOS / NIÑOS / JÓVENES / ADULTOS Y BENEFICIOS CATABÓLICAS.
GH: ACCIONES ANABÓLICAS SANA Y BIEN RECONOCIDO LA GH ESTIMULAR EL EMPLEO EN STAT HORMONALES COMO CATABÓLICO (FRENTE), INCLUYENDO CIRUGÍA, QUEMADURAS, NUTRICIÓN PARENTERAL, BANCARROTA ORGÁNICA Y BENEFICIOS PARA LOS QUE TIENEN DISCAPACIDADES INMUNOLÓGICO, Y QUE LOS BENEFICIOS QUE ÉSTAS SEAN EVIDENTES, PERO DEBE SER UTILIZADO CON DOMINIO PARA PROFESIONALES ENDOCRINÓLOGOS. FISIOLOGÍA-ENDOCRINOLOGÍA-NEUROENDOCRINOLOGÍA-GENÉTICA-ENDOCRINO-PEDIATRÍA (FRACCIONAMIENTO DE ENDOCRINOLOGÍA): DR. JOÃO SANTOS CAIO JR. ET DRA. HENRIQUETA VERLANGIERI CAIO.
Eficiencia GH ADNr es muy importante, independientemente de su aplicación principal (somatotropina) que tiene indicaciones específicas para el crecimiento en altura (altura) longitudinal. Se hicieron posibles estas aplicaciones después del descubrimiento en 1985 por la enzima Genentech con una especie de función de lápiz, que eliminó el reconocimiento individual de quien pertenecía ADN, descartando varias enfermedades graves, tales como la formación de priones o ECJ - la enfermedad de Creutzfeldt Jakob. El balance negativo de nitrógeno en los pacientes críticos es en parte atribuible a la insensibilidad a la GH, así como una reducción en la producción y acción de IGF-1 (crecimiento similar a la insulina factor 1). La GH se administra en pacientes post-quirúrgicos, así como en los individuos normales que están recibiendo alimentación intravenosa hipocalórica, los resultados en la reversión al balance positivo de nitrógeno.
Dr. João Santos Caio Jr.
Endocrinologia – Neuroendocrinologista
CRM 20611
Dra. Henriqueta V. Caio
Endocrinologista – Medicina Interna
CRM 28930
1. A DGH é uma condição médica, causada por problemas que surgem na glândula pituitária, em que o corpo não produz quantidade suficiente de GH...
http://hormoniocrescimentoadultos.blogspot.com.
2. O GH, também chamado de somatotropina, é um hormônio polipeptídeo que estimula o crescimento e reprodução das células...
http://longevidadefutura.blogspot.com
3. A DGH tem uma variedade de diferentes efeitos negativos em diferentes idades; p. ex., em recém-nascidos, as manifestações primárias podem ser hipoglicemia ou micropênis, enquanto mais tarde na infância, a falha do crescimento é mais provável...
http://imcobesidade.blogspot.com
AUTORIZADO O USO DOS DIREITOS AUTORAIS COM CITAÇÃO
DOS AUTORES PROSPECTIVOS ET REFERÊNCIA BIBLIOGRÁFICA.
Referências Bibliográficas:
Caio Jr, João Santos, Dr.; Endocrinologista, Neuroendocrinologista, Caio,H. V., Dra. Endocrinologista, Medicina Interna – Van Der Häägen Brazil, São Paulo, Brasil; Sandberg DE, Colsman M, Voss LD. Short stature and quality of life: a review of assumptions and evidence. In: Pescovitz OH, Eugster E, eds. Pediatric Endocrinology: Mechanisms, Manifestations, and Management. Philadelphia, Pa: Lippincourt, Williams & Wilkins; 2004:191-202; Vance ML, Mauras N. Growth hormone therapy in adults and children. New Engl J Med. 1999;341:1206-1216; Carrel AL, Moerchen V, Myers SE, Bekx MT, Whitman BY, Allen DB. Growth hormone improves mobility and body composition in infants and toddlers with Prader-Willi syndrome. J Pediatr. 2004;145:744-749; Cassidy SB. Prader-Willi syndrome in the new millennium.Endocrinologist. 2001;10(suppl 1):1S-73S; Sandberg DE, Voss LD. The psychosocial consequences of short stature: a review of the evidence. Best Pract Res Clin Endocrinol Metab. 2002;16:449-463; Rosenfeld RG. Is growth hormone deficiency a viable diagnosis? J Clin Endocrinol Metab. 1997;82:349-351; Allen DB, Fost N. hGH for short stature: ethical issues raised by expanded access. J Pediatr. 2004;144:648-652; Finkelstein BS, Imperiale TF, Speroff T, Marrero U, Radcliffe DJ, Cuttler L. Effect of growth hormone therapy on height in children with idiopathic short stature: a meta-analysis. Arch Pediatr Adolesc Med. 2002;156:230-240; Sandberg DE, Michael P. Psychosocial stresses related to short stature: does their presence imply psychiatric dysfunction? In: Drotar D, ed. Assessing Pediatric Health-Related Quality of Life and Functional Status: Implications for Research. Mahwah, NJ: Lawrence Erlbaum Associates; 1998:287-312; Zimet GD, Cutler M, Litvene M, Dahms W, Owens R, Cuttler L. Psychological adjustment of children evaluated for short stature: a preliminary report. J Dev Behav Pediatr. 1995;16:264-270; Sandberg DE, Brook AE, Campos SP. Short stature: a psychosocial burden requiring growth hormone therapy? Pediatrics. 1994;94:832-840; Ross JL, Sandberg DE, Rose SR, et al. Psychological adaptation in children with idiopathic short stature treated with growth hormone or placebo. J Clin Endocrinol Metab. 2004;89:4873-4878; Theunissen NC, Kamp GA, Koopman HM, Zwinderman KA, Vogels T, Wit JM. Quality of life and self-esteem in children treated for idiopathic short stature. J Pediatr. 2002;140:507-515; Slyper A. The safety and effectiveness of human growth hormone using pharmacological dosing. Med Hypotheses. 1995;45:523-528; Finkelstein BS, Singh J, Silvers JB, Marrero U, Neuhauser D, Cuttler L. Patient attitudes and preferences regarding treatment: GH therapy for childhood short stature. Horm Res. 1999;51(Suppl 1):67-72.
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